*Quadrupole time-of-flight instrument provides resolution of ~20,000 (100 m/z) - 45,000 (>1000 m/z) that is independent of acquisition rate *Agilent Jet Stream dual ESI source: analysis of positively or negatively charged ions by electrospray ionization (ESI) reference nebulizer continually introduces reference mass solution to provide drift correction superheated nitrogen concentrates ions and increases sensitivity *66 vial autosampler, 0.1 - 40.0 ul injection volume *800 bar pump, 0.1 - 5.0 ml/min flow rate LC system: Agilent 1260 Infinity II Prime QTOF is a valuable confirmation technique for synthesis and drug discovery because the chance that a different compound has the same exact mass is extremely low. This provides mass to charge ratios reportable to 4 decimal places. The instrument is used to separate components based on their affinity for the stationary phase of the LC column, while the quadrupole time-of-flight MS provides high resolution analysis of the separated compound based on highly accurate time-of-flight measurements. The Agilent LC-QTOF is located in Chem 175.
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